Prediction of regulatory modules comprising microRNAs and target genes
نویسندگان
چکیده
منابع مشابه
Prediction of regulatory modules comprising microRNAs and target genes
MOTIVATION MicroRNAs (miRNAs) are small endogenous RNAs that can play important regulatory roles via the RNA-interference pathway by targeting mRNAs for cleavage or translational repression. We propose a computational method to predict miRNA regulatory modules (MRMs) or groups of miRNAs and target genes that are believed to participate cooperatively in post-transcriptional gene regulation. RE...
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در این پایان نامه، در ابتدا برای مدول ها روی دامنه های پروفر شرایط معادل به دست آورده ایم و خواصی از ددکیند مدول ها روی دامنه های پروفر مشخص کرده ایم. در ادامه برای ددکیند مدول های با تولید متناهی روی حلقه های به طور صحیح بسته شرایط معادل به دست آورده ایم و ددکیند مدول های ضربی را مشخص کرده ایم. گزاره هایی در مورد بعد ددکیند مدول ها بیان کرده ایم. در پایان، قضایای lying over و going down را برا...
15 صفحه اولMicroRNAs--targeting and target prediction.
MicroRNAs (miRNAs) are a class of small noncoding RNAs that can regulate many genes by base pairing to sites in mRNAs. The functionality of miRNAs overlaps that of short interfering RNAs (siRNAs), and many features of miRNA targeting have been revealed experimentally by studying miRNA-mimicking siRNAs. This review outlines the features associated with animal miRNA targeting and describes curren...
متن کاملMicroRNAs: Target Recognition and Regulatory Functions
MicroRNAs (miRNAs) are endogenous approximately 23 nt RNAs that play important gene-regulatory roles in animals and plants by pairing to the mRNAs of protein-coding genes to direct their posttranscriptional repression. This review outlines the current understanding of miRNA target recognition in animals and discusses the widespread impact of miRNAs on both the expression and evolution of protei...
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Objective(s):An earlier meta-analysis on gene expression data derived from four microarray, two cDNA library, and one SAGE experiment had identified RGS5 as one of only ten non-housekeeping genes that were reported to be expressed in human trabecular meshwork (TM) cells by all studies. RGS5 encodes regulator of G-protein signaling-5. The TM tissue is the route of aqueous fluid outflow, and is r...
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ژورنال
عنوان ژورنال: Bioinformatics
سال: 2005
ISSN: 1367-4803,1460-2059
DOI: 10.1093/bioinformatics/bti1116